European Journal of Clinical Pharmacology. All patients (n = 573) had SLE according to the American College of Rheumatology classification criteria 33 and had received HCQ for at least 6 months, without modification of the dosage for 2 months and with the daily dosage stable over time (either 200 mg every day or 400 mg every day). On multivariate analysis, high body mass index (P = 0.008), no treatment with corticosteroids (P = 0.04), increased time between the last tablet intake and measurement of blood HCQ concentrations (P = 0.017), low platelet count (P < 0.001), low neutrophil count (P < 0.001), and high estimated creatinine clearance (P < 0.001) were associated with low blood HCQ concentrations. reply Adherence to hydroxychloroquine in patients with systemic lupus: Contrasting results and weak correlation between assessment tools. The optimal daily dose of HCQ in SLE is a subject of controversy, and few data have been published on the pharmacologic management of HCQ therapy. Blood HCQ levels can be quantified by high‐performance liquid chromatography (HPLC). What we have to know about corticosteroids use during Sars-Cov-2 infection. To avoid any bias, by convention, we always analyzed the first sample. Hydroxychloroquine reduces the risk of covid-19 in patients with rheumatic diseases: myth or reality?.
We also studied 3 patients receiving long‐term dialysis. This finding is probably consistent with a longer delay between intake of the last tablet and measurement of the blood HCQ concentration being independently associated with a low blood HCQ concentration (P < 0.001). A pharmacokinetic/pharmacodynamic relationship has been found in different situations, and a very low blood concentration of HCQ is a simple marker of nonadherence to treatment. A Prospective International Study on Adherence to Treatment in 305 Patients With Flaring SLE: Assessment by Drug Levels and Self‐Administered Questionnaires. The median blood HCQ concentration was 949 ng/ml (range 208–3,316 ng/ml) in those receiving HCQ once a day and 867 ng/ml (213–2,452 ng/ml) in those receiving HCQ twice a day (P = 0.01). The authors concluded that the mean elimination half‐life of HCQ was 123 ± 45 hours. of cigarettes smoked/day (among smokers), Time from intake of last tablet to measurement of blood HCQ concentration, hours. Of note, this level of 1,000 ng/ml at 1 week seems higher than what we observed. Accordingly, most of the patients had received their most recent dose of HCQ in the previous 24 hours. Members of the Plaquenil Lupus Systemic Study Group are as follows: Leonardo Astudillo, Cristina Belizna, Nadia Belmatoug, Olivier Benveniste, Audrey Benyamine, Holly Bezanahary, Patrick Blanco, Olivier Bletry, Bahram Bodaghi, Pierre Bourgeois, Benoît Brihaye, Emmanuel Chatelus, Richard Damade, Eric Daugas, Christian De‐Gennes, Jean‐François Delfraissy, Céline Delluc, Aurélien Delluc, Pierre Duhaut, Alain Dupuy, Isabelle Durieu, Hang‐Korng Ea, Dominique Farge, Christian Funck‐Brentano, Frédérique Gandjbakhch, Justine Gellen‐Dautremer, Pascale Ghillani‐Dalbin, Bertrand Godeau, Cécile Goujard, Catherine Grandpeix, Claire Grange, Lamiae Grimaldi, Gaëlle Guettrot, Loïc Guillevin, Eric Hachulla, Jean‐Robert Harle, Julien Haroche, Pierre Hausfater, Jean Jouquan, Gilles Kaplanski, Homa Keshtmand, Mehdi Khellaf, Olivier Lambotte, David Launay, Philippe Lechat, Hervé Levesque, Olivier Lidove, Eric Liozon, Kim Ly, Matthieu Mahevas, Kubéraka Mariampillai, Alexis Mathian, Karin Mazodier, Marc Michel, Nathalie Morel, Luc Mouthon, Lucile Musset, Rokiya Ngack, Jacques Ninet, Eric Oksenhendler, Jean‐Luc Pellegrin, Olivier Peyr, Anne‐Marie Piette, Vincent Poindron, Fabienne Roux, David Saadoun, Sabrinel Sahali, Bernadette Saint‐Marcoux, Françoise Sarrot‐Reynauld, Yoland Schoindre, Damien Sene, Jacques Serratrice, Aude Servais, Pascal Seve, Jean Sibilia, Claude Simon, Christelle Sordet, Benjamin Terrier, Salim Trad, Jean‐François Viallard, Elisabeth Vidal, Bertrand Wechsler, Pierre‐Jean Weiller.
A Case of Breakthrough COVID-19 during Hydroxychloroquine Maintenance. Because this measurement is increasingly being used, these data might be useful for clinicians.
Understanding the dynamics of hydroxychloroquine blood levels in lupus nephritis. Low hydroxychloroquine blood levels in patients who have had gastric bypass surgery.